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Five nights with 39 anniversary download10/16/2023 However, many physiological variables also change when subjects go from wake to sleep, anesthesia, or coma. For instance, compared to wakefulness, during non-rapid eye movement (NREM) sleep TMS elicits a larger positive–negative wave, fewer phase-locked oscillations and an overall simpler response. When subjects become unconscious, there is a characteristic change in the way the cerebral cortex responds to perturbations, as can be assessed using transcranial magnetic stimulation and electroencephalography (TMS–EEG).
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